Chronic Uremia Stimulates LDL Carbamylation and Atherosclerosis
نویسندگان
چکیده
منابع مشابه
Chronic uremia stimulates LDL carbamylation and atherosclerosis.
Carbamylated LDL (cLDL) is a potential atherogenic factor in chronic kidney disease (CKD). However, whether elevated plasma cLDL associates with atherosclerosis in vivo is unknown. Here, we induced CKD surgically in apolipoprotein E-deficient (ApoE(-/-)) mice fed a high-fat diet to promote the development of atherosclerosis. These mice had two- to threefold higher plasma levels of both oxidized...
متن کاملCarbamylation-derived products: bioactive compounds and potential biomarkers in chronic renal failure and atherosclerosis.
BACKGROUND Carbamylation is a posttranslational modification of proteins resulting from the nonenzymatic reaction between isocyanic acid and specific free functional groups. This reaction alters protein structural and functional properties and thus contributes to molecular ageing. Many studies have shown the involvement of carbamylated proteins in diseases, especially in chronic renal failure a...
متن کاملVascular disease and atherosclerosis in uremia.
Epidemiological and clinical studies have shown that cardiovascular disease in patients with end-stage renal disease (ESRD) is frequently related to damage of large conduit arteries. Arterial disease is responsible for the high incidence of ischemic heart disease, peripheral artery diseases, left ventricular hypertrophy and congestive heart failure. The vascular complications in ESRD are due to...
متن کاملHemodynamic studies in chronic uremia.
SUMMARY Hemodynamic functions and blood volume were observed in patients with chronic uremia. Thirty-one patients had clinical features of circulatory congestion and 37 did not. The degree of anemia and acidosis was comparable in both groups. However, cre-atinine clearance was significantly lower in patients with circulatory congestion. Both groups of patients had greater blood pressure, heart ...
متن کاملEndothelial dysfunction, atherosclerosis and thrombosis in uremia--possibilities of intervention.
Chronic renal failure is a state of prominent endothelial dysfunction, accelerated atherosclerosis, high incidence of thromboembolic complications and excess cardiovascular mortality. We reviewed up-to-date experimental and clinical data showing close and deleterious links between these entities. Emerging therapeutic interventions aimed at improvement of endothelial function and better clinical...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2010
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2010040365